《神域少女》是一部现代都市幻想动画，讲述了四个普普通通的女孩一步步转变为传奇的神域少女的故事。受到一个预言的召唤，艾克娜、卡莉娅、埃茉拉和佩佩为了保护自己的家园，齐心协力共同对抗邪恶的敌人——以尼可拉法和黑暗巴恩的为领导的反派组织。她们是令人刮目相看的英雄，一路共同成长为最伟大的勇士和最亲密的朋友。
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